We report here evidence that these phospholipids are able to modulate the function of homomeric P 2 X 3 and heteromeric P 2 X 2/3 purinoceptors expressed in dorsal root ganglion (DRG) nociceptors and in heterologous expression systems. The phospholipids phosphatidylinositol 4,5-bisphosphate (PIP 2) and phosphatidylinositol 3,4,5-trisphosphate (PIP 3) are involved in functional modulation of several types of ion channels.
Mo, Gary Bernier, Louis-Philippe Zhao, Qi Chabot-Doré, Anne-Julie Ase, Ariel R Logothetis, Diomedes Cao, Chang-Qing Séguéla, Philippeīackground P 2 X 3 and P 2 X 2/3 purinergic receptor-channels, expressed in primary sensory neurons that mediate nociception, have been implicated in neuropathic and inflammatory pain responses. Subtype-specific regulation of P 2 X 3 and P 2 X 2/3 receptors by phosphoinositides in peripheral nociceptors
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